Knowledge hub

Importance of secondary screening with clinical isolates for anti- leishmania drug discovery

This study demonstrates the potential value of using Leishmania strains isolated from VL patients for monitoring drug sensitivty and resistance emergence, as well as for systematic use in high-throughput screening (HTS) during novel anti-leishmanial drug discovery.

8 Aug 2018
Academic paper
Operational research

Visceral leishmaniasis elimination targets in India, strategies for preventing resurgence

Abstract

"Introduction: Visceral leishmaniasis (VL) is a fatal parasitic disease caused by a parasite belonging to the Leishmania donovani complex and transmitted by infected female Phlebotomous argentipes sand flies. The VL elimination strategy in the Indian subcontinent (ISC), which has a current goal of reducing the incidence of VL to below 1/10,000 of population by the year 2020, consists of rapid detection and treatment of VL to reduce the number of human reservoirs as well as vector control using indoor residual spraying (IRS). However, as the incidence of VL declines toward the elimination goal, greater targeting of control methods will be required to ensure appropriate early action to prevent the resurgence of VL.

Area covered: We discuss the current progress and challenges in the VL elimination program and strategies to be employed to ensure sustained elimination of VL.

Expert commentary: The VL elimination initiative has saved many human lives; however, for VL elimination to become a reality in a sustained way, an intense effort is needed, as substantial numbers of endemic subdistricts (primary health centers (PHCs) blocks level) are yet to reach the elimination target. In addition to effective epidemiological surveillance, appropriate diagnostic and treatment services for VL at PHCs will be needed to ensure long-term sustainability and prevent reemergence of VL."

30 Jul 2018
Academic paper
Improving surveillance
India

Free on-line course "The Control and Elimination of Visceral Leishmaniasis (kala-azar)"

Developed by the London School of Hygiene and Tropical Medicine together with the guidance, expertise and training material from KalaCORE partners and the support of UK aid by the UK government, we invite you to join the new open free on-line course on the Control and Elimination of Visceral Leishmaniasis (VL).

The course serves as a unique platform to learn about the practical tools, the requirements and the complexities of VL control and elimination programmes - like those supported by KalaCORE, in South Asia and East Africa.

To register to the course and to find out more information visit https://www.futurelearn.com/courses/visceral-leishmaniasis/ 

 

24 Jul 2018
Training material
Training health workers
Ethiopia, India, Bangladesh, Sudan, Nepal, South Sudan

WHO bi-regional consultation on the status of Leishmaniasis control and surveillance in East Africa

Report following the East African regional meeting in Nairobi over June 2017. It reviews progress and challenges in leishmaniasis control activities and strategies in Ethiopia, Kenya, Somalia, South Sudan, Sudan and Uganda during 2016 and sumamrises key actions for 2017 forwards.

9 Jul 2018
Policy paper

Insecticide susceptibility status of Phlebotomus argentipes and polymorphisms in voltage-gated sodium channel (vgsc) gene in Kala-azar endemic areas of West Bengal, India

This study evaluated insecticide susceptibility of Phlebotomus argentipes sand flies in West Bengal, India and looked at associated polymorphisms in insecticide target genes. Key findings:

- Sand fly populations were found resistant to DDT but susceptible to deltamethrin and malathion.

- Mutations L1014S and L1014F were also detected. The latter was found associated with deltamethrin/DDT resistance.

The authors conclude that Type II pyrethroid tolerability can be an indication of emergence of resistance against it. Malathion may be used as an alternative in the study areas if needed in future.

2 Jul 2018
Academic paper
Operational research
India
200.56 KB
pdf

KalaCORE Project M&E Guide

The Guide has been developed and used by KalaCORE, in paralellel to the implementation and operational research activities udertaken. Robust and appropriate monitoring and evaluation (M&E) together can increase the potential for projects to contribute to achieving and demonstrating the goal of the programme.

Several target intervention M&E areas that are covered here include:

  • Clinical health worker training to improve diagnosis & treatment
  • Laboratory training to improve diagnosis
  • Supervision of health workers
  • Upgrading health facilities
  • Improve supply of drugs & diagnostics
  • Behaviour change communication (BCC)
  • Strengthening surveillance
  • Vector control
19 Jun 2018
Protocol
200.56 KB
pdf

KalaCORE Project M&E Guide

The Guide has been developed and used by KalaCORE, in paralellel to the implementation and operational research activities udertaken. Robust and appropriate monitoring and evaluation (M&E) together can increase the potential for projects to contribute to achieving and demonstrating the goal of the programme.

Several target intervention M&E areas that are covered here include:

  • Clinical health worker training to improve diagnosis & treatment
  • Laboratory training to improve diagnosis
  • Supervision of health workers
  • Upgrading health facilities
  • Improve supply of drugs & diagnostics
  • Behaviour change communication (BCC)
  • Strengthening surveillance
  • Vector control
19 Jun 2018
Training material

Policy Recommendations From Transmission Modeling for the Elimination of Visceral Leishmaniasis in the Indian Subcontinent

"This paper draws together the key policy-relevant conclusions from recent transmission modeling of VL, and presents new predictions for VL incidence under the interventions recommended by the WHO using the latest transmission models."
1 Jun 2018
Academic paper
India, Bangladesh, Nepal

The initial effectiveness of liposomal amphotericin B (AmBisome) and miltefosine combination for treatment of visceral leishmaniasis in HIV co-infected patients in Ethiopia: A retrospective cohort study

This study examined the initial effectiveness of a combination treatment of AmBisome and miltefosine in HIV / VL co-infected patients in Ethiopia.

1 Jun 2018
Academic paper
Case management
Ethiopia

New insights into leishmaniasis in the immunosuppressed

Review describing the challenges of VL treatment and control for immunocompromised individuals.

21 May 2018
Academic paper

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