Knowledge hub

Importance of secondary screening with clinical isolates for anti- leishmania drug discovery

This study demonstrates the potential value of using Leishmania strains isolated from VL patients for monitoring drug sensitivty and resistance emergence, as well as for systematic use in high-throughput screening (HTS) during novel anti-leishmanial drug discovery.

8 Aug 2018
Academic paper
Operational research

Free on-line course "The Control and Elimination of Visceral Leishmaniasis (kala-azar)"

Developed by the London School of Hygiene and Tropical Medicine together with the guidance, expertise and training material from KalaCORE partners and the support of UK aid by the UK government, we invite you to join the new open free on-line course on the Control and Elimination of Visceral Leishmaniasis (VL).

The course serves as a unique platform to learn about the practical tools, the requirements and the complexities of VL control and elimination programmes - like those supported by KalaCORE, in South Asia and East Africa.

To register to the course and to find out more information visit https://www.futurelearn.com/courses/visceral-leishmaniasis/ 

 

24 Jul 2018
Training material
Training health workers
Ethiopia, India, Bangladesh, Sudan, Nepal, South Sudan

WHO bi-regional consultation on the status of Leishmaniasis control and surveillance in East Africa

Report following the East African regional meeting in Nairobi over June 2017. It reviews progress and challenges in leishmaniasis control activities and strategies n Ethiopia, Kenya, Somalia, South Sudan, Sudan and Uganda during 2016 and sumamrises key actions for 2017 forwards.

9 Jul 2018
Policy paper

Insecticide susceptibility status of Phlebotomus argentipes and polymorphisms in voltage-gated sodium channel (vgsc) gene in Kala-azar endemic areas of West Bengal, India

This study evaluated insecticide susceptibility of Phlebotomus argentipes sand flies in West Bengal, India and looked at associated polymorphisms in insecticide target genes. Key findings:

- Sand fly populations were found resistant to DDT but susceptible to deltamethrin and malathion.

- Mutations L1014S and L1014F were also detected. The latter was found associated with deltamethrin/DDT resistance.

The authors conclude that Type II pyrethroid tolerability can be an indication of emergence of resistance against it. Malathion may be used as an alternative in the study areas if needed in future.

2 Jul 2018
Academic paper
Operational research
India
200.56 KB
pdf

KalaCORE Project M&E Guide

The Guide has been developed and used by KalaCORE, in paralellel to the implementation and operational research activities udertaken. Robust and appropriate monitoring and evaluation (M&E) together can increase the potential for projects to contribute to achieving and demonstrating the goal of the programme.

Several target intervention M&E areas that are covered here include:

  • Clinical health worker training to improve diagnosis & treatment
  • Laboratory training to improve diagnosis
  • Supervision of health workers
  • Upgrading health facilities
  • Improve supply of drugs & diagnostics
  • Behaviour change communication (BCC)
  • Strengthening surveillance
  • Vector control
19 Jun 2018
Training material
200.56 KB
pdf

KalaCORE Project M&E Guide

The Guide has been developed and used by KalaCORE, in paralellel to the implementation and operational research activities udertaken. Robust and appropriate monitoring and evaluation (M&E) together can increase the potential for projects to contribute to achieving and demonstrating the goal of the programme.

Several target intervention M&E areas that are covered here include:

  • Clinical health worker training to improve diagnosis & treatment
  • Laboratory training to improve diagnosis
  • Supervision of health workers
  • Upgrading health facilities
  • Improve supply of drugs & diagnostics
  • Behaviour change communication (BCC)
  • Strengthening surveillance
  • Vector control
19 Jun 2018
Protocol

Policy Recommendations From Transmission Modeling for the Elimination of Visceral Leishmaniasis in the Indian Subcontinent

"This paper draws together the key policy-relevant conclusions from recent transmission modeling of VL, and presents new predictions for VL incidence under the interventions recommended by the WHO using the latest transmission models."
1 Jun 2018
Academic paper
India, Bangladesh, Nepal

The initial effectiveness of liposomal amphotericin B (AmBisome) and miltefosine combination for treatment of visceral leishmaniasis in HIV co-infected patients in Ethiopia: A retrospective cohort study

This study examined the initial effectiveness of a combination treatment of AmBisome and miltefosine in HIV / VL co-infected patients in Ethiopia.

1 Jun 2018
Academic paper
Case management
Ethiopia

New insights into leishmaniasis in the immunosuppressed

Review describing the challenges of VL treatment and control for immunocompromised individuals.

21 May 2018
Academic paper

A fine scale eco-epidemiological study on endemic visceral leishmaniasis in north ethiopian villages

In an effort to better understand tranmission of VL in Northern Ethiopia, this study evaluated entomological, epidemiological and ecological factors associated with VL in three endemic villages.

Key findings include:

  • Vertisols (also known as black-cotton soil) were found positively related with Phlebotomus orientalis sand fly populations. Vertisols around houses could conribute to anthroponotic transmission.
  • From those found infected with Leishmania donovani the majority was under 15 years old. Also significantly more males succumbed to VL than females.
  • The study reported high abudance of infected individuals with high parasitemias who remain asymptomatic. These individuals may serve as a reservoir for anthroponotic transmission.
23 Apr 2018
Academic paper
Improving surveillance, Operational research
Ethiopia

Pages